Linaclotide API

Alternative Names

English Alternative Name：Linaclotide Acetate, Linzess, L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)

L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclic (1->6),(2->10),(5->13)-tris(disulfide)

Physicochemical Properties

CAS No.: 851199-59-2

Purity: ≥99% (HPLC)
Molecular Formula: C₅₉H₇₉N₁₅O₂₁S₆
Theoretical Molecular Weight: 1526.8 Da
Appearance: White to off-white lyophilized powder
Storage Conditions: -20°C±5°C (dry, protected from light)
Sequence: Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr (contains 3 disulfide bonds)
Solubility:Soluble in DMSO (slightly heated), methanol ((slightly heated)), water (slightly heated)

Indications

1. For irritable bowel syndrome with constipation (IBS-C) in adults.
2. For chronic idiopathic constipation (CIC).

Structural Formula